The critical importance of IL‐4/IL‐13 axis as a driver of TH2 immunity in allergic asthma has been established with IL‐4Rα being central mediator of disease pathology.1, 4 We and others have previously demonstrated cell‐specific function of IL‐4Rα signaling in the development of allergic disease.1, 11, 16, 18, 19, 20, 21, 40 However, the temporal role of IL‐4Rα signaling in vivo, during sensitization and effector phases of allergic disease, is not completely clear. The gene discussed is IL4R; the disease is allergic asthma.