IL4R and Increased total eosinophil count: IL‐4Rα signaling is important in establishing a TH2‐driven allergic airway pathology, and its absence, for example, IL‐4Rα‐deficient mice, leads to amelioration of IL‐4/IL‐13‐dependent allergic airway disease.41, 42, 43 We observed a reduction in AHR, eosinophilia, mucus hypersecretion, and pathology during temporal deletion of IL‐4Rα after sensitization phase or during effector phase.