MAP2 and Alzheimer disease: Consistent with this observation, we also found a decrease in total area covered by neurites in the AD neurons, as measured histologically by anti-β-tubulin III (Tuj1) and anti-microtubule associated protein 2 (MAP2) antibody labeling, while somal size was not affected (Figure 2A–C, Figure 2—figure supplement 1A,B, Figure 2—figure supplement 2A–C).