Mutations in the human EPHB4 gene are associated with various pathologies, such Capillary Malformation-Arteriovenous Malformation 2 (Amyere et al., 2017) and vein of Galen aneurysmal malformations (Vivanti et al., 2018), which are known to be associated with heart failure. The gene discussed is EPHB4; the disease is Capillary malformation - arteriovenous malformation.