Mutations in the human EPHB4 gene are associated with various pathologies, such Capillary Malformation-Arteriovenous Malformation 2 (Amyere et al., 2017) and vein of Galen aneurysmal malformations (Vivanti et al., 2018), which are known to be associated with heart failure. This evidence concerns the gene EPHB4 and heart failure.