Although interleukin (IL)‐18 production by epithelial cells is critical in driving the pathologic breakdown of barrier integrity in the colitis model (Dupaul‐Chicoine et al, 2010), we observed no significant difference for colonic IL‐18 expression between DSS‐treated WT and GPx8−/− mice (Fig 1H). The gene discussed is GPX8; the disease is colitis.