We therefore treated GPx8−/− mice with VX‐765, a caspase‐1/4 inhibitor (Stack et al, 2005; Wannamaker et al, 2007), or N‐acetylcysteine (NAC), an ROS scavenger, to confirm the importance of the ROS‐modulating gene in the inflammasome pathway and colitis. Here, GPX8 is linked to colitis.