In our RNA‐Seq study, six GBC patients were recruited and the expression level of ERɑ (ESR1), but not PR or HER2, was significantly increased (Figure 1A) in tumour tissue, which was further verified using QPCR in 21 paired cases (Figure 1B), suggesting ER signalling might be frequently altered in GBC. The gene discussed is PGR; the disease is neoplasm.