Tamoxifen is a typical anti‐oestrogen drug which has achieved quite satisfactory results in breast cancer treatment and also shows good results in a variety of tumour studies.11 Over the past 20 years, there have been more than 25 clinical studies reported that high doses of TAM clinical trials, including melanoma, glioma, have achieved positive results.12, 13 It is generally believed that TAM plays a major role in the competitive binding and inhibition of ER,14, 15 while some other studies claimed different mechanism, such as inhibiting protein kinase C (PKC).16, 17. This evidence concerns the gene ESR1 and breast cancer.