By evaluating ERɑ expression in 123 GBC cases using IHC (ERɑ low, score 0‐1 and ERɑ high, score 2‐3), we were able to found that increased level of ERɑ was correlated with worse clinical outcome, tumour size and TMN stages (Figure 1C,D and Table 1). The gene discussed is ESR1; the disease is neoplasm.