BRAF and colorectal carcinoma: Some literature shows that MSI status may not have a prognostic relevance in CRC,37 but Yang et al suggested that microsatellite stable (MSS) + BRAF mutation was a poor prognostic factor, while MSI + BRAF mutation was related to a moderate prognosis, and MSS/MSI + BRAF wild type was associated with a more favorable outcome.38 Murcia et al reported a similar result, which suggested that the combination of MSS, BRAF mutation and CIMP positive related to poor prognosis.39 As there are few researches on the relationship between MSI status and gene mutation, more attention on this issue is needed.