GHRL and obesity due to melanocortin 4 receptor deficiency: In addition, ipragliflozin reportedly reduces body fat mass by increasing lipolysis and fatty acid oxidation but not lean mass or bone mineral content in high‐fat diet‐induced obese rats (Yokono et al., 2014), and reverses abnormal regulation of appetite‐regulating hormones, such as neuropeptide Y and ghrelin, which are strongly correlated with obesity and lipid abnormalities (Tahara, Kondo, Takasu, & Tomiyama, 2018).