INS and obesity due to melanocortin 4 receptor deficiency: Abnormally high plasma levels of proinflammatory cytokines have been reported among type 2 diabetes patients with NAFLD, which may be induced by several conditions, including hyperglycemia, insulin resistance, and obesity, causing impaired insulin signaling, cell damage, neutrophil chemotaxis, hepatic stellate cell activation, and apoptosis (Shams, Al‐Gayyar, & Barakat, 2011).