Genetic leptin‐deficient (ob/ob), leptin‐resistant (db/db), or Agouti mutation (KK/Ay) mice, and methionine/choline‐deficient (MCD) diet, CDAA diet‐, or high‐fat diet‐fed models (Anstee & Goldin, 2006; Ibrahim, Hirsova, Malhi, & Gores, 2016; Nakamura & Terauchi, 2013) are examples of animal models of NASH that have been used to examine a number of traditional and novel agents to date (Hansen et al., 2017). This evidence concerns the gene LEP and metabolic dysfunction-associated steatohepatitis.