HDAC1 and chronic kidney disease: Specifically at the nucleus, CKD sera induced a significant increase in HDAC1 (77.5 ± 2.9% vs 50.3 ± 2.4% of nuclei labelled area in control samples, n = 6, P < .01), which was prevented by DF (41.8 ± 5.2% of nuclei labelled area, n = 6, P < .01 vs CKD).