ICAM‐1 and TLR4 expression on cell surfaces and vWF content were higher in ECs exposed to the CKD patients’ sera when compared to control sera (1.5 ± 0.2%, 0.8 ± 0.1%, and 7.5 ± 0.9% vs 0.6 ± 0.1%, 0.4 ± 0.1%, and 3.9 ± 0.2%, respectively, n = 6, P < .05). The gene discussed is VWF; the disease is chronic kidney disease.