Far1 deficiency results in reduced plasmalogens and a peroxisomal disorder associated severe intellectual disability, epilepsy and cataracts.50 Plasmalogens are essential membrane components that have many diverse roles, including the protection against ROS injury.51 Sindelar et al52 showed that the oxidative products of plasmalogens generated by various free radicals and singlet oxygen are unable to further propagate lipid peroxidation, suggesting plasmalogens may terminate lipid oxidation. Here, FAR1 is linked to Intellectual disability.