BRCA2 and breast cancer: In addition, men who carry BRCA2 variants also have an increased risk of developing breast cancer.20 Thus, we collected samples from men, and Sanger sequencing revealed that IV:3 had wild‐type alleles of BRCA2, whereas IV:10 carried the heterozygous missense mutation of the gene BRCA2: c.7007G>T (Figure 2L).