It is certainly possible to also use to treat cocaine addiction the A2AR antagonists used in treatment of Parkinson’s disease like istradefylline (Nourianz) (Borroto-Escuela and Fuxe 2019; Borroto-Escuela et al. 2018a; Fuxe and Borroto-Escuela 2019). Here, ADORA2A is linked to cocaine dependence.