Among the changes that may be relevant in the case of coexistence of depression and obesity, the increase in the level of G-6-P, glycogen, and reduction of the membrane GLUT4 in the frontal cortex seem to be particularly important, because these changes were present only in PS-R/HFD group, but not in control/HFD or PS-R/STD. The gene discussed is SLC2A4; the disease is depressive disorder.