EGFR and colorectal cancer: EGFR-mutated or EGFR-overexpressing colorectal cancer is associated with higher rates of radiological tumor response to cetuximab, an anti-EGF antibody, and response to treatment may be predicted by early decrease in tumor size on follow-up imaging acquired by 8 weeks after cetuximab initiation has also been associated with improved long-term survival [41, 59].