A representative example of these phenomenon which can be observed on imaging is histologic transformation of indolent lymphoma: follicular lymphoma, a common type of indolent non-Hodgkin lymphoma, can transform into the aggressive diffuse large b cell lymphomas (DLBCL) by means of the stepwise acquisition of a set of mutations, most notably involving TP53 [15, 16]. The gene discussed is TP53; the disease is diffuse large B-cell lymphoma.