TP53 and lung carcinoma: Thus, we aimed to accomplish the following goals: (1) isolate Cr-LCSCs from 3 lung cancer cell lines with different p53 backgrounds; (2) investigate the involvement of mt p53 in regulating the Cr-LCSC self-renewal pattern; (3) investigate the effect of mt p53 on the tumorigenicity of Cr-LCSCs; and (4) compare the density of macrophage infiltration in subcutaneously implanted wt and mt p53 Cr-LCSC xenografts.