PDCD1 and non-small cell lung carcinoma: The PD-1 monoclonal antibody Opdivo (nivolumab) was approved by the US Food and Drug Administration in 2015 and was finally approved by the China Food and Drug Administration for the treatment of non-small-cell lung cancer in China on June 15, 2018, followed by another PD-1 monoclonal antibody, Keytruda (pembrolizumab), on July 26.