In the meta-analysis [28], glyburide ranked the worst with the highest incidence of macrosomia, preeclampsia, hyperbilirubinemia, neonatal hypoglycemia, preterm birth, and low birth weight; metformin (plus insulin when required) has the lowest risk of macrosomia, pregnancy hypertension, LGA, RDS, preterm birth, and low birth weight. This evidence concerns the gene INS and newborn respiratory distress syndrome.