Interestingly, repetitive treatment of aqueous α-GalCer (in DMSO- and detergent-dissolved aqueous forms) was shown to prevent and stop the recurrence of spontaneous diabetes development in nonobese diabetic (NOD) mice; however, there was no enhancement of the regulatory activity of spleen CD62L+ regulatory T cells toward diabetogenic T cells [23]. Here, SELL is linked to diabetes mellitus.