Compared with the Atherosclerosis + Vector group, the mRNA and protein expressions of NF-κBp65 (Figures 4(a) and 4(b)), PCNA (Figures 4(a) and 4(c)), p-p38 MAPK (Figures 4(a) and 4(d)), p-JNK (Figures 4(a) and 4(e)), and p-ERK1/2 (Figures 4(a) and 4(f)) were significantly decreased in the Atherosclerosis + Knockdown group and increased in the Atherosclerosis + Overexpression group. The gene discussed is MAPK8; the disease is atherosclerosis.