In nonalcoholic steatohepatitis-associated HCC cell lines, a panel of 10 miRNAs was experimentally proven to suppress the most frequent carcinogenesis pathways, especially Wnt/β-catenin and TGF-β, the signal transducer and activator of transcription 3 (STAT3), extracellular signal-regulated kinase 1 (ERK/MAPK), PPARα/RXRα, PTEN, RAR, cell cycle regulation, stem cell regulation, c-myc, and the mechanistic target of rapamycin (mTOR) and amphiregulin (AREG), EGF, and NF-κB signaling [15]. The gene discussed is AREG; the disease is hepatocellular carcinoma.