In conclusion, the results of the present study showed that the variant genotype and variant T allele of the MSX1 rs8670 SNP increased the risk of hypodontia in the studied population, and it might be considered a risk factor for frontal agenesis The presence of the variant A allele of AXIN2 rs2240308 is associated with frontal agenesis but not with lateral agenesis. Here, AXIN2 is linked to Hypodontia.