Mild proinflammatory state (i.e., as revealed by increased IL-6, C-reactive protein [CRP], leukocyte count, and lymphocyte activation pathways), hypercoagulation, anemia, impaired endocrine system, micronutrient deficiencies, neuromuscular deficits have been also associated with the development of frailty (22, 26, 34–37). This evidence concerns the gene CRP and anemia (phenotype).