CRP and thrombophilia: Mild proinflammatory state (i.e., as revealed by increased IL-6, C-reactive protein [CRP], leukocyte count, and lymphocyte activation pathways), hypercoagulation, anemia, impaired endocrine system, micronutrient deficiencies, neuromuscular deficits have been also associated with the development of frailty (22, 26, 34–37).