While tumor burden and treatment were not predictors of survival in the multivariable model, when correcting for BRAF-status and LDH, subjects with high IL-6 and high IL-8 had a 3.1 times increased risk of death (95% CI, 1.4–14.2) compared to subjects with low IL-6 and low IL-8 (p = 0.012, Figure 5A). This evidence concerns the gene CXCL8 and neoplasm.