Another identified unfavorable gene, CECR1, was demonstrated to serve a critical function in M2-like macrophages, mediating cross-talk between macrophages and pericytes in glioblastoma via paracrine PDGFB-PDGFRβ signaling, promoting pericyte recruitment and migration and tumor angiogenesis (29). The gene discussed is PDGFB; the disease is neoplasm.