The results showed that Cx43 expression was a clearly negative factor with tumor grades (<i>I</i> <sup>2</sup> = 34%, <i>P</i> < 0.001) and beneficial for OS (<i>n</i> = 3, HR 2.62, 95%CI 1.47-4.68; <i>P</i> = 0.001). The gene discussed is GJA1; the disease is neoplasm.