Transposon insertion in one of two RASGAP genes, neurofibromin1 (Nf1) and RAS p21 protein activator (Rasa1), might function as the causal role of the mammary tumor development in a tumor mouse model generated by the activation of a mutagenic T2Onc2 transposon via expression of a transposase driven by the keratin K5 promoter in a p53+/− background (74). The gene discussed is RASA1; the disease is neoplasm.