CXCL12 and colorectal carcinoma: Moreover, KEGG pathway enrichment analysis showed significant enrichment of chemokine signaling pathways, including of the genes GNG4, GNG3, ADCY2, CXCL12, and CXCR5. The CXC family of chemokines and their receptors are crucial for modulating inflammation and antitumor immunity, both of which are key factors in CRC progression.