The proposed, new classification system is composed of 11 genomic subgroups of AML including AML with NPM1 mutation; AML with mutated chromatin, RNA-splicing genes or both; AML with TP53 mutations, chromosomal aneuploidy or both; AML with inv (16) or t (16, 16); AML with biallelic CEBPA mutations; AML with t (8, 21); AML with MLL fusion genes, AML with inv (3); t(3, 3), GATA2, MECOM; AML with IDH2-R172 and no other class-defining lesions; AML with t (6, 9). The gene discussed is TP53; the disease is acute myeloid leukemia.