CALR and neoplasm: Noting that surface calreticulin is best known for promoting phagocytosis by antigen-presenting cells and thus initiating anti-tumor immunity, the authors showed that upon recovery from chemotherapy, the normal PBMCs from patients expressing high surface calreticulin, as compared to low surface calreticulin, showed a gene expression pattern reflecting enrichment of TH1 polarization, T cell activation, CD8+ T-cell cytotoxicity and NK-related genes.