The immunostimulatory effects of radiation therapy and certain chemotherapeutic agents has been proposed to be mediated via p53- activated TLR and IFN type 1 pathway (195) and by extension, dysregulation of these pathways downstream of mutated p53 may mediate resistance to these therapies in multiple malignancies including TP53-mutated AML. Here, TP53 is linked to acute myeloid leukemia.