In the phase 1b dose-escalation and expansion study of the BCL2 inhibitor, venetoclax, combined with azacitadine or decitabine, in elderly patients with AML, the rate of CR + CRi, the median duration of CR + CRi and the median overall survival in patients with TP53 mutation compared to all comers was 47%, 5.6, 7.2 months vs. 67%, 11.3 and 17.5 months (138). The gene discussed is TP53; the disease is acute myeloid leukemia.