They observed that a robust response could be identified following attainment of CR post-induction chemotherapy and was sustained in patients with a durable remission compared to a low number or absence of NPM1-mutated specific T cells in patients with leukemia relapse suggesting that a mutated NPM1-specific T cell response is inversely correlated with MRD and relapse (143). The gene discussed is NPM1; the disease is leukemia.