AKT1 and cancer: Piperlongumine (Figure 5) (125), swainsonine (Figure 5) (126), and sinomenine (Figure 5) (127) induce apoptosis and inhibit cancer cell growth through the PI3K/Akt/mTOR pathway, with decreased levels of p-Akt and p-mTOR, as evidenced by the results of Western blot analysis and immunofluorescence.