Siming Zhao et al. also reported that a significantly increased burden of mutation in 14 genes, including PIK3CA, TP53, PPP2R1A, KRAS, FBXW7, CHD4, TAF1, PTEN, HCFC1R1, CDKN1A, CTDSPL, YIPF3, SPOP, and FAM132A, in the whole-exome sequencing of 57 uterine serous carcinoma compared to their matched normal DNA from the same patients (28). This evidence concerns the gene SPOP and endometrial serous adenocarcinoma.