For example, circRNA-microarray expression analysis of doxorubicin (ADM)-resistant THP1 cells revealed a set of 49 circRNAs with altered expression, and elevated circPAN3 (product PAN3 gene) in recurrent and refractory AML was defined as a key player in drug resistance in AML (23). This evidence concerns the gene PAN3 and acute myeloid leukemia.