However, IV iron therapy is recommended during the 2nd and 3rd trimesters for women with severe anemia (Hb < 9 g/dL) and risk factors (coagulation disorders and placenta previa), emergency situations that require prompt resolution of anemia (paleness, tachycardia, tachypnea, syncope, heart failure, respiratory failure, angina pectoris, and signs of cerebral hypoxia), and noncompliance to oral iron because of intolerance (gastrointestinal adverse events) [3, 4]. This evidence concerns the gene GSTM1 and anemia (phenotype).