Our data show that the antioxidative activities of SOD and catalase are significantly lower in synchisis scintillans group compared with patients affected by vitreoretinal disorders, confirming that dysregulation of SOD and catalase activities at the vitreous base may be critical in the pathophysiology of oxidative stress-related vitreoretinopathies. This evidence concerns the gene SOD1 and vitreoretinal degeneration.