To date, candidate gene association studies identified high myopia-associated genes such as collagen, type I, alpha 1 (COL1A1), transforming growth factor beta 1 (TGFB1), transforming growth beta-induced factor (TGIF), lumican (LUM), hepatocyte growth factor (HGF), myocilin (MYOC), paired box 6 (PAX6), and uromodulin-like 1 (UMODL1). The gene discussed is COL1A1; the disease is myopia.