Additionally, the endothelial dysfunction that exists in the PE is probably due to hypoxia/reperfusion, which causes oxidative stress that provokes placental production of a large number of antiangiogenic factors, such as sFlt-1 and sEndoglin, and reduction of angiogenic factors vascular endothelial growth factor (VEGF) and placental growth factor (PIGF). This evidence concerns the gene VEGFA and endothelial dysfunction.