The findings of the present study suggest that LOX-1, NOX2, and ROS are involved in mediating hypercholesterolemia-induced endothelial dysfunction in the retina, which is in concert with a study in cerebral blood vessels reporting that NOX2-derived ROS abrogated nitric oxide function in ApoE-/- mice [40]. The gene discussed is OLR1; the disease is endothelial dysfunction.