APOE and age-related macular degeneration: Intriguingly, previous studies in genetically modified animal models of atherosclerosis, including ApoE-/- mice, reported on pathological changes in outer retinal layers, such as lipoidal degenerations and basal deposits in the Bruch's membrane that resemble alterations observed in ageing human eyes, with some functional and morphologic alterations similar to those found in age-related macular degeneration [60–63].