Treatment with NC001-8 reduced the overproduction of ROS and expression of cleaved caspase 3 by H2O2 toxicity and upregulated NRF2 and NQO1 in PD-iPSC-derived DAergic neurons, suggesting its neuroprotective and antioxidative potentials in DAergic neurons from patients with PD. This evidence concerns the gene NQO1 and Parkinson disease.