CASP3 and Parkinson disease: Consistent with previous findings [24], treatment with H2O2 significantly reduced the expression levels of NRF2 (PD1: fold change, 0.24; PD2: fold change, 0.38; p < 0.05; Figure 5(b)) and NQO1 (PD1: fold change, 0.48; PD2: fold change, 0.13; p < 0.05; Figure 5(b)) and increased the levels of cleaved caspase 3 (PD1: fold change, 6.47; PD2: fold change, 9.32; p < 0.05; Figure 5(b)) when compared to untreatment in DAergic neurons derived from PD-iPSCs.