ESR1 and breast carcinoma: As alcohol intake is associated with ER+ cases of breast cancer much more than with ER- cases of this disease [8, 9], the mechanism analysis of alcohol-associated breast cancer indicates that cellular levels of Pol III gene transcription are significantly different in ER- breast cell lines, not ER- nontumor breast cell lines (MCF-10A, MCF-10F, and MCF12A) or ER- breast cancer cell lines (MDA-MB235 and SKRB-3), from ER+ breast cancer cell lines (MCF-7 and TDT477) [20].