Although PIK and PKB are able to phosphorylate Brf1 [40–42], our studies indicate that alcohol activates JNK1, but not JNK2 [19], while JNK1 indeed mediates alcohol-induced Brf1 expression in both hepatocellular carcinoma and breast cancer cells [19, 20]. This evidence concerns the gene BRF1 and hepatocellular carcinoma.