As mentioned above, these factors, such as signaling molecules (such as JNK1 and MSK1), hormone receptor (such as ERα), transcription factors (such as Runx2, BRCA1), epigenetic modifications (such as histone H3 phosphorylation), carcinogens (such as alcohol, EGF, DEN), medicine (Tam), and others [ [20, 31, 33, 66–69, 73] and (unpublished)], which impact Brf1 expression, lead to deregulation of Pol III genes and cause cell proliferation, cell transformation, and eventually breast cancer development. The gene discussed is ESR1; the disease is breast carcinoma.