As a potent antioxidant factor, nuclear factor erythroid 2-related factor 2 (Nrf-2) level is closely correlated with the progression of asthma, and antioxidant markers including superoxide-dismutase (SOD) and glutathione peroxidase (GPX) exhibit low expression in severe bronchial asthma which might be associated with Nrf-2 [15]. The gene discussed is NFE2L2; the disease is asthma.