As shown in Figure 4(a), all of 11 immunomodulators (LAG-3, TIM-3, CTLA-4, IFN-γ, ICOS, ICAM-1, TIGIT, PD-1, PDL-1, NKG2A, and VISTA) were significantly increased in ccRCC samples compared with normal kidney samples. Here, ICOS is linked to nonpapillary renal cell carcinoma.