ICOS and neoplasm: In this study, we determined 11 immunomodulators that are involved in tumor escape mechanisms and found 9 immunomodulators (LAG-3, TIM-3, CTLA-4, IFN-γ, ICOS, ICAM-1, TIGIT, NKG2A, and VISTA) that were upregulated in both high-immune score group and high-stromal score group.