Compared with those in the control group, VEGF and ET-1 levels were significantly increased in each model group at the end of induction (p < 0.01), especially in the IMQ + STZ and IMQ + STZ + BSS groups, suggesting that the three interventions (psoriasis, blood stasis syndrome, and glucose and lipid metabolism disorders) caused different degrees of microcirculation disorders. Here, EDN1 is linked to psoriasis.