The score of STAT3-positive cells was the highest in the IMQ + STZ + BSS group; STAT3-positive cells in the IMQ + STZ + BSS and IMQ + BSS groups were darker than those in the IMQ group (p < 0.05), suggesting that glucose and lipid metabolism disorders and blood stasis syndrome promoted the proliferation and differentiation of keratinocytes (KCs), and that the expression of STAT3 was positively correlated with PASI score. The gene discussed is STAT3; the disease is Disorder of lipid metabolism.