In mice, plasma levels and hippocampal protein expression of cytokines such as NLR family pyrin domain containing 3 (NLRP3), cysteine-dependent aspartate-specific programmed-1 (caspase-1), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-18 (IL-18), and tumor necrosis factor-β (TNF-β) have revealed the potential roles of drugs in the management of pyroptosis and chronic inflammation [14]. The gene discussed is IL18; the disease is inflammatory response.