AR and prostate neoplasm: Recent observations on the reduced levels of the Androgen Receptor (AR) in prostate CSC due to the hypermethylation of the promoter region of AR provided the mechanistic basis to Tian and collaborators [102] to use decitabine (5-aza-2'-deoxycytidine-5azadC) to inhibit DNA methyltransferases (DNMTs) in prostate tumors.