This is particularly true for the BCR/ABL1 fusion gene and the PDGFRA, PDGFRB, and FGFR1 genes [22] as well as for TET2 mutations, observed in MDS, CMML, and in B and mainly T LPDs [23], for SF3B1 mutations, associated with both the MDS-RS phenotype and B-CLL [24, 25]. This evidence concerns the gene TET2 and B-cell chronic lymphocytic leukemia.