AM, AS, and their ingredients, such as astragalus polysaccharides (APS), astragalus saponin (AST), astragaloside IV (AS-IV), calycosin, ferulic acid, formononetin, and Z-ligustilide (LIG), were proved to suppress the growth of tumor cells, the release of inflammatory cytokines, the expression of NF-κB and STAT3, and the activation of protumoral macrophages and T cells [8, 16–23]. The gene discussed is STAT3; the disease is neoplasm.