In mice with normal immunity, the serum IFN-γ (a Th1 cytokine) level and the tumoral expression of Arg1+ cells (M2 TAMs) were elevated, but the IL-4 (a Th2 cytokine) level and the expression of iNOS+ cells (M1 TAMs) were diminished after tumor inoculation (Figure 7). This evidence concerns the gene IL4 and neoplasm.