Univariate analysis revealed that preoperative serum IL6 > 8.45 pg/ml, preoperative serum IL8 > 68 pg/ml, preoperative serum TNF − α > 14.9 pg/ml, MVI, and maximum tumor size > 5 cm were significantly correlated with RFS in HCC patients who accepted radical hepatectomy (Table 2). The gene discussed is CXCL8; the disease is hepatocellular carcinoma.