PTCH1 and nevoid basal cell carcinoma syndrome: Its related syndrome, basal cell nevus syndrome (BCNS), is characterized by skeletal abnormalities, jaw keratocysts, and calcification of brain structures in addition to carcinoma (Kimonis et al., 1997), and mutations in the Ptch1/2 and SuFu genes have been found in BCNS patients (Johnson et al., 1996; Goodrich et al., 1997; Kimonis et al., 1997; De Mori et al., 2017).