In a related animal experiment, mice with a CAD-linked LDL receptor-associated protein 6 (LRP6) mutation (LRP6R611C) showed coronary and aortic intimal hyperplasia even in the absence of mechanical vascular injury, which is mainly due to excessive VSMCs proliferation without excessive inflammation (Srivastava et al., 2015). Here, LRP6 is linked to coronary artery disorder.