At present, CHD associated with GATA6 gene mutations include bicuspid aortic valve (BAV), ventricular septal defect (VSD), patent ductus arteriosus (PDA), atrial septal defect (ASD), persistent truncus arteriosus (PTA), and tetralogy of Fallot (TOF) (Kodo et al., 2009; Lin et al., 2010; Maitra et al., 2010; Kodo et al., 2012; Wang et al., 2012; Zheng et al., 2012; Bui et al., 2013; Huang et al., 2013; Li et al., 2014; Gharibeh et al., 2018; Xu et al., 2018). Here, GATA6 is linked to ventricular septal defect.