NAT1 and breast carcinoma: The NAT1 gene, located on chromosome 8p22, encodes one of two human enzymes that are known to metabolize arylamine- and hydrazine-type drugs (Butcher and Minchin, 2012), and in this regard, a previous study has reported that low NAT1 expression resulted in a distinctly poor response to chemotherapy in breast cancer patients (Minchin and Butcher, 2018).