Yagi et al. (Yagi et al., 2010) identified the occurrence of three methylation epigenotypes (high-, intermediate-, and low-methylation) in CRC, and found that the high-methylation epigenotype was correlated with MSI-high and BRAF-mutation(+), whereas KRAS-mutation(+) CRC associated with an intermediate-methylation epigenotype showed worse prognosis. Here, BRAF is linked to colorectal carcinoma.