To date, studies have identified the methylation of several genes, including Claudin11 (Lee et al., 2016), APC2 (Butcher and Minchin, 2012), and ZNF331 (Liu et al., 2015), that are considered to be potential epigenetic biomarkers for the diagnosis and prognosis of CRC. This evidence concerns the gene APC2 and colorectal carcinoma.