Recently, Scumpia et al. showed that both TLR and STING pathways are activated a few hours after macrophage infection with live S. aureus and compete for the regulation of ~95% of the induced genes; in particular, TLR signaling predominantly activated a proinflammatory program while STING signaling activated an antiviral/type I IFN response (13). Here, STING1 is linked to infection.