Furthermore, we did not find significant changes associated with the expression of conventional functional Treg markers, CD15s, CD226, CD161, and HLA-DR (Supplementary Figure 4) or in the expression of the proliferation marker Ki-67 (Figure 5D) in CD45RA− CD25hiFOXP3+HELIOS+ Tregs from SLE patients. This evidence concerns the gene CD226 and systemic lupus erythematosus.