IFNA1 and systemic lupus erythematosus: To investigate if the observed Treg expansion could also be recapitulated at the transcriptional level, we next investigated the transcriptional profile of total CD4+ T cells in a subset of (i) four SLE patients where we had previously detected a high transcriptional IFN signature (IFNhi) in total PBMCs (27); (ii) two SLE patients with low IFN signature (IFNlow); and (iii) four healthy donors (Supplementary Figure 6A and Supplementary Table 2).