FOXP3 and systemic lupus erythematosus: Regardless of how Tregs were delineated, we found a consistent increase in the frequency of both CD127lowCD25hi (5.7 vs. 8.5% and 6.3 vs. 7.5% in cohorts 1 and 2, respectively; Figure 1B) and FOXP3+ CD127lowCD25hi (4.6 vs. 7.3% and 4.6 vs. 5.4% in cohorts 1 and 2, respectively; Figure 1C) Tregs in blood from SLE patients compared to age-matched healthy volunteers.