A meta-analysis of the combined datasets revealed an estimated increase of 0.514% in the frequency of Tregs in circulation per copy of the autoimmunity associated PTPN22 Trp620 allele (SE = 9.2 × 10−3, Pcombined = 3.2 × 10−6; Table 2). The gene discussed is PTPN22; the disease is Autoimmunity.