Similarly to the phenotype of CD45RA− FOXP3+HELIOS+ Tregs, CD45RA− Teffs from SLE patients also showed evidence for increased expression of T-cell activation and proliferation markers, namely PD-1, Ki-67, TIGIT and CD15s (Supplementary Figure 5). The gene discussed is MKI67; the disease is systemic lupus erythematosus.